Role of uterine artery doppler at 14–22 weeks of gestation in predicting preeclampsia and intrauterine growth restriction

Shadab Maqsood, Akash Deep, Saima Wani, Sheikh Riaz Rasool, Abdul Haseeb Wani, Nadia Khursheed, Inzamam Wani

Abstract

Hypertensive disorders, particularly pre-eclampsia, are major contributors to maternal mortality worldwide. Uterine artery Doppler ultrasonography, which measures indices such as the pulsatility index (PI) and resistance index (RI), has proven to be an effective tool for the early prediction of pre-eclampsia and intrauterine growth restriction (IUGR). This study aimed to evaluate the predictive value of uterine artery Doppler indices between 14–22 weeks of gestation for these adverse pregnancy outcomes.This study included 480 pregnant women between 14–22 weeks of gestation. Uterine artery Doppler measurements, including PI, RI, and the presence of diastolic notching, were recorded. Participants were followed up for the development of pre-eclampsia and IUGR. The sensitivity, specificity, and predictive values of the Doppler indices were calculated.Pre-eclampsia was observed in 6.9% (n = 33) of participants, while IUGR occurred in 5% (n = 24). Pre-eclamptic women exhibited significantly higher uterine artery PI (1.0 ± 0.15) and RI (0.75 ± 0.07) compared to normotensive women (p < 0.001). The sensitivity and specificity of uterine artery PI in predicting pre-eclampsia were 52% and 83.3%, respectively. Uterine artery notching demonstrated a sensitivity of 58.3% and a specificity of 90% in predicting IUGR. Uterine artery Doppler ultrasonography is a valuable tool for predicting pre-eclampsia and IUGR.

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References

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